Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer

Telomerase is expressed in early human development and then becomes silenced in most normal tissues. Because ~90% of primary human tumors express telomerase and generally maintain very short telomeres, telomerase is carefully regulated, particularly in large, long-lived mammals. In the current repor...

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Detalles Bibliográficos
Autores principales: Kim, Wanil, Ludlow, Andrew T., Min, Jaewon, Robin, Jerome D., Stadler, Guido, Mender, Ilgen, Lai, Tsung-Po, Zhang, Ning, Wright, Woodring E., Shay, Jerry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169358/
https://www.ncbi.nlm.nih.gov/pubmed/27977688
http://dx.doi.org/10.1371/journal.pbio.2000016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169358/
https://www.ncbi.nlm.nih.gov/pubmed/27977688
http://dx.doi.org/10.1371/journal.pbio.2000016

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