Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and mechanisms underlying cellular dysfunction are poorly understood. We found that toxic lipids relevant to three different LSDs disrupt multiple lysosomal and other cellular functions. Unbiased drug discovery revealed...

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Detalles Bibliográficos
Autores principales: Folts, Christopher J., Scott-Hewitt, Nicole, Pröschel, Christoph, Mayer-Pröschel, Margot, Noble, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169359/
https://www.ncbi.nlm.nih.gov/pubmed/27977664
http://dx.doi.org/10.1371/journal.pbio.1002583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169359/
https://www.ncbi.nlm.nih.gov/pubmed/27977664
http://dx.doi.org/10.1371/journal.pbio.1002583

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