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Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex

Mechanisms that prevent aggregation and promote folding of nascent G protein–coupled receptors (GPCRs) remain poorly understood. We identified chaperonin containing TCP-1 subunit eta (CCT7) as an interacting partner of the β-isoform of thromboxane A(2) receptor (TPβ) by yeast two-hybrid screening. C...

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Detalles Bibliográficos
Autores principales: Génier, Samuel, Degrandmaison, Jade, Moreau, Pierrick, Labrecque, Pascale, Hébert, Terence E., Parent, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170604/
https://www.ncbi.nlm.nih.gov/pubmed/27708139
http://dx.doi.org/10.1091/mbc.E16-04-0224