A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin

PURPOSE: The analgesic and opioid-sparing effects of nonsteroidal anti-inflammatory drugs can be beneficial in postoperative populations. Hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac is an injectable formulation of diclofenac solubilized with HPβCD that is administered as a low-volume intravenous...

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Detalles Bibliográficos
Autores principales: Goldwater, Ronald, Kramer, William G, Hamilton, Douglas A, Lang, Eric, Wang, Jianyuan, Madden, Donna E, Lacouture, Peter G, Ramaiya, Atulkumar, Carr, Daniel B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170674/
https://www.ncbi.nlm.nih.gov/pubmed/28008289
http://dx.doi.org/10.2147/CPAA.S98437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170674/
https://www.ncbi.nlm.nih.gov/pubmed/28008289
http://dx.doi.org/10.2147/CPAA.S98437

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