The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35

In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, which inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in Alzheimer’s disease (AD) model mice, the peptide sp...

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Detalles Bibliográficos
Autores principales: Amin, Niranjana D., Zheng, Yali, BK, Binukumar, Shukla, Varsha, Skuntz, Susan, Grant, Philip, Steiner, Joseph, Bhaskar, Manju, Pant, Harish C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170856/
https://www.ncbi.nlm.nih.gov/pubmed/27630261
http://dx.doi.org/10.1091/mbc.E15-12-0857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170856/
https://www.ncbi.nlm.nih.gov/pubmed/27630261
http://dx.doi.org/10.1091/mbc.E15-12-0857

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