Synthesis of dimeric analogs of adenophostin A that potently evoke Ca(2+) release through IP(3) receptors

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are tetrameric intracellular channels through which many extracellular stimuli initiate the Ca(2+) signals that regulate diverse cellular responses. There is considerable interest in developing novel ligands of IP(3)R. Adenophostin A (AdA) is a potent...

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Detalles Bibliográficos
Autores principales: Vibhute, Amol M., Pushpanandan, Poornenth, Varghese, Maria, Koniecnzy, Vera, Taylor, Colin W., Sureshan, Kana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171214/
https://www.ncbi.nlm.nih.gov/pubmed/28066549
http://dx.doi.org/10.1039/c6ra19413c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171214/
https://www.ncbi.nlm.nih.gov/pubmed/28066549
http://dx.doi.org/10.1039/c6ra19413c

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