Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

Neurexins are transmembrane synaptic cell adhesion molecules involved in the development and maturation of neuronal synapses. In the present study, we report that Nrxn3β is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-cleaving protease γ-secretase, producing secreted ne...

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Detalles Bibliográficos
Autores principales: Borcel, Erika, Palczynska, Magda, Krzisch, Marine, Dimitrov, Mitko, Ulrich, Giorgio, Toni, Nicolas, Fraering, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171655/
https://www.ncbi.nlm.nih.gov/pubmed/27991559
http://dx.doi.org/10.1038/srep39310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171655/
https://www.ncbi.nlm.nih.gov/pubmed/27991559
http://dx.doi.org/10.1038/srep39310

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