Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis

Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a relatively low frequency in NB and the downstream function of p53 is intact in NB cell lines. Wip1 is a negative regulator of p53 and hindrance...

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Detalles Bibliográficos
Autores principales: Chen, Zhenghu, Wang, Long, Yao, Dayong, Yang, Tianshu, Cao, Wen-Ming, Dou, Jun, Pang, Jonathan C., Guan, Shan, Zhang, Huiyuan, Yu, Yang, Zhao, Yanling, Wang, Yongfeng, Xu, Xin, Shi, Yan, Patel, Roma, Zhang, Hong, Vasudevan, Sanjeev A., Liu, Shangfeng, Yang, Jianhua, Nuchtern, Jed G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171816/
https://www.ncbi.nlm.nih.gov/pubmed/27991505
http://dx.doi.org/10.1038/srep38011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171816/
https://www.ncbi.nlm.nih.gov/pubmed/27991505
http://dx.doi.org/10.1038/srep38011

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