The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

Autophagy and the unfolded protein response (UPR) both promote activation of hepatic stellate cells (HSC), however the link between the two stimuli remains unclear. Here we have explored the role of X-box binding protein 1 (XBP1), one of three UPR effector pathways and sought to establish the interd...

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Detalles Bibliográficos
Autores principales: Kim, Rosa S., Hasegawa, Daisuke, Goossens, Nicolas, Tsuchida, Takuma, Athwal, Varinder, Sun, Xiaochen, Robinson, Christopher L., Bhattacharya, Dipankar, Chou, Hsin-I, Zhang, David Y., Fuchs, Bryan C., Lee, Youngmin, Hoshida, Yujin, Friedman, Scott L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172197/
https://www.ncbi.nlm.nih.gov/pubmed/27996033
http://dx.doi.org/10.1038/srep39342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172197/
https://www.ncbi.nlm.nih.gov/pubmed/27996033
http://dx.doi.org/10.1038/srep39342

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