Loss of miR-140 is a key risk factor for radiation-induced lung fibrosis through reprogramming fibroblasts and macrophages

Radiation-induced lung fibrosis (RILF) is a common side effect for patients with thoracic cancer receiving radiation therapy. RILF is characterized by excessive collagen deposition mediated by TGF-β1 and its downstream factor SMAD3, but the exact molecular mechanism leading to fibrosis is yet to be...

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Detalles Bibliográficos
Autores principales: Duru, Nadire, Zhang, Yongshu, Gernapudi, Ramkishore, Wolfson, Benjamin, Lo, Pang-Kuo, Yao, Yuan, Zhou, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172237/
https://www.ncbi.nlm.nih.gov/pubmed/27996039
http://dx.doi.org/10.1038/srep39572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172237/
https://www.ncbi.nlm.nih.gov/pubmed/27996039
http://dx.doi.org/10.1038/srep39572

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