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Genome-wide Analysis of WD40 Protein Family in Human

The WD40 proteins, often acting as scaffolds to form functional complexes in fundamental cellular processes, are one of the largest families encoded by the eukaryotic genomes. Systematic studies of this family on genome scale are highly required for understanding their detailed functions, but are cu...

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Autores principales: Zou, Xu-Dong, Hu, Xue-Jia, Ma, Jing, Li, Tuan, Ye, Zhi-Qiang, Wu, Yun-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172248/
https://www.ncbi.nlm.nih.gov/pubmed/27991561
http://dx.doi.org/10.1038/srep39262
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author Zou, Xu-Dong
Hu, Xue-Jia
Ma, Jing
Li, Tuan
Ye, Zhi-Qiang
Wu, Yun-Dong
author_facet Zou, Xu-Dong
Hu, Xue-Jia
Ma, Jing
Li, Tuan
Ye, Zhi-Qiang
Wu, Yun-Dong
author_sort Zou, Xu-Dong
collection PubMed
description The WD40 proteins, often acting as scaffolds to form functional complexes in fundamental cellular processes, are one of the largest families encoded by the eukaryotic genomes. Systematic studies of this family on genome scale are highly required for understanding their detailed functions, but are currently lacking in the animal lineage. Here we present a comprehensive in silico study of the human WD40 family. We have identified 262 non-redundant WD40 proteins, and grouped them into 21 classes according to their domain architectures. Among them, 11 animal-specific domain architectures have been recognized. Sequence alignment indicates the complicated duplication and recombination events in the evolution of this family. Through further phylogenetic analysis, we have revealed that the WD40 family underwent more expansion than the overall average in the evolutionary early stage, and the early emerged WD40 proteins are prone to domain architectures with fundamental cellular roles and more interactions. While most widely and highly expressed human WD40 genes originated early, the tissue-specific ones often have late origin. These results provide a landscape of the human WD40 family concerning their classification, evolution, and expression, serving as a valuable complement to the previous studies in the plant lineage.
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spelling pubmed-51722482016-12-28 Genome-wide Analysis of WD40 Protein Family in Human Zou, Xu-Dong Hu, Xue-Jia Ma, Jing Li, Tuan Ye, Zhi-Qiang Wu, Yun-Dong Sci Rep Article The WD40 proteins, often acting as scaffolds to form functional complexes in fundamental cellular processes, are one of the largest families encoded by the eukaryotic genomes. Systematic studies of this family on genome scale are highly required for understanding their detailed functions, but are currently lacking in the animal lineage. Here we present a comprehensive in silico study of the human WD40 family. We have identified 262 non-redundant WD40 proteins, and grouped them into 21 classes according to their domain architectures. Among them, 11 animal-specific domain architectures have been recognized. Sequence alignment indicates the complicated duplication and recombination events in the evolution of this family. Through further phylogenetic analysis, we have revealed that the WD40 family underwent more expansion than the overall average in the evolutionary early stage, and the early emerged WD40 proteins are prone to domain architectures with fundamental cellular roles and more interactions. While most widely and highly expressed human WD40 genes originated early, the tissue-specific ones often have late origin. These results provide a landscape of the human WD40 family concerning their classification, evolution, and expression, serving as a valuable complement to the previous studies in the plant lineage. Nature Publishing Group 2016-12-19 /pmc/articles/PMC5172248/ /pubmed/27991561 http://dx.doi.org/10.1038/srep39262 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zou, Xu-Dong
Hu, Xue-Jia
Ma, Jing
Li, Tuan
Ye, Zhi-Qiang
Wu, Yun-Dong
Genome-wide Analysis of WD40 Protein Family in Human
title Genome-wide Analysis of WD40 Protein Family in Human
title_full Genome-wide Analysis of WD40 Protein Family in Human
title_fullStr Genome-wide Analysis of WD40 Protein Family in Human
title_full_unstemmed Genome-wide Analysis of WD40 Protein Family in Human
title_short Genome-wide Analysis of WD40 Protein Family in Human
title_sort genome-wide analysis of wd40 protein family in human
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172248/
https://www.ncbi.nlm.nih.gov/pubmed/27991561
http://dx.doi.org/10.1038/srep39262
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