First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics

OBJECTIVE: To evaluate the safety and pharmacokinetics of MIV-150 and zinc acetate in a carrageenan gel (PC-1005). Acceptability, adherence, and pharmacodynamics were also explored. DESIGN: A 3-day open-label safety run-in (n = 5) preceded a placebo-controlled, double-blind trial in healthy, HIV-neg...

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Detalles Bibliográficos
Autores principales: Friedland, Barbara A., Hoesley, Craig J., Plagianos, Marlena, Hoskin, Elena, Zhang, Shimin, Teleshova, Natalia, Alami, Mohcine, Novak, Lea, Kleinbeck, Kyle R., Katzen, Lauren L., Zydowsky, Thomas M., Fernández-Romero, José A., Creasy, George W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Materias:
Basic and Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172848/
https://www.ncbi.nlm.nih.gov/pubmed/27437826
http://dx.doi.org/10.1097/QAI.0000000000001136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172848/
https://www.ncbi.nlm.nih.gov/pubmed/27437826
http://dx.doi.org/10.1097/QAI.0000000000001136

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