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First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics

OBJECTIVE: To evaluate the safety and pharmacokinetics of MIV-150 and zinc acetate in a carrageenan gel (PC-1005). Acceptability, adherence, and pharmacodynamics were also explored. DESIGN: A 3-day open-label safety run-in (n = 5) preceded a placebo-controlled, double-blind trial in healthy, HIV-neg...

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Detalles Bibliográficos
Autores principales:	Friedland, Barbara A., Hoesley, Craig J., Plagianos, Marlena, Hoskin, Elena, Zhang, Shimin, Teleshova, Natalia, Alami, Mohcine, Novak, Lea, Kleinbeck, Kyle R., Katzen, Lauren L., Zydowsky, Thomas M., Fernández-Romero, José A., Creasy, George W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Materias:	Basic and Translational Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172848/ https://www.ncbi.nlm.nih.gov/pubmed/27437826 http://dx.doi.org/10.1097/QAI.0000000000001136

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