Glaucarubinone sensitizes KB cells to paclitaxel by inhibiting ABC transporters via ROS-dependent and p53-mediated activation of apoptotic signaling pathways

Multidrug resistance (MDR) is considered to be the major contributor to failure of chemotherapy in oral squamous cell carcinoma (SCC). This study was aimed to explore the effects and mechanisms of glaucarubinone (GLU), one of the major quassinoids from Simarouba glauca DC, in potentiating cytotoxici...

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Detalles Bibliográficos
Autores principales: Karthikeyan, Subburayan, Hoti, Sugeerappa Laxmanappa, Nazeer, Yasin, Hegde, Harsha Vasudev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173140/
https://www.ncbi.nlm.nih.gov/pubmed/27304668
http://dx.doi.org/10.18632/oncotarget.9865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173140/
https://www.ncbi.nlm.nih.gov/pubmed/27304668
http://dx.doi.org/10.18632/oncotarget.9865

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