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Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses

OBJECTIVE: Previous studies have shown that differential DNA methylation is associated with SLE susceptibility. How DNA methylation affects the clinical heterogeneity of SLE has not been fully defined. We conducted this study to identify differentially methylated CpG sites associated with nephritis...

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Detalles Bibliográficos
Autores principales: Mok, Amanda, Solomon, Olivia, Nayak, Renuka R, Coit, Patrick, Quach, Hong L, Nititham, Joanne, Sawalha, Amr H, Barcellos, Lisa F, Criswell, Lindsey A, Chung, Sharon A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174796/
https://www.ncbi.nlm.nih.gov/pubmed/28074145
http://dx.doi.org/10.1136/lupus-2016-000183