RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2

The RAG1/RAG2 endonuclease initiates V(D)J recombination at antigen receptor loci but also binds to thousands of places outside of these loci. RAG2 localizes directly to lysine 4 trimethylated histone 3 (H3K4me3) through a plant homeodomain (PHD) finger. The relative contribution of RAG2-dependent a...

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Detalles Bibliográficos
Autores principales: Maman, Yaakov, Teng, Grace, Seth, Rashu, Kleinstein, Steven H., Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175335/
https://www.ncbi.nlm.nih.gov/pubmed/27436288
http://dx.doi.org/10.1093/nar/gkw633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175335/
https://www.ncbi.nlm.nih.gov/pubmed/27436288
http://dx.doi.org/10.1093/nar/gkw633

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