Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

Poly(ADP-ribose) (PAR) is a posttranslational modification predominantly synthesized by PAR polymerase-1 (PARP-1) in genome maintenance. PARP-1 detects DNA damage, and damage detection is coupled to a massive increase PAR production, primarily attached to PARP-1 (automodification). Automodified PARP...

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Detalles Bibliográficos
Autores principales: Steffen, Jamin D., McCauley, Michael M., Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175350/
https://www.ncbi.nlm.nih.gov/pubmed/27530425
http://dx.doi.org/10.1093/nar/gkw710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175350/
https://www.ncbi.nlm.nih.gov/pubmed/27530425
http://dx.doi.org/10.1093/nar/gkw710

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