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Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

Poly(ADP-ribose) (PAR) is a posttranslational modification predominantly synthesized by PAR polymerase-1 (PARP-1) in genome maintenance. PARP-1 detects DNA damage, and damage detection is coupled to a massive increase PAR production, primarily attached to PARP-1 (automodification). Automodified PARP...

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Detalles Bibliográficos
Autores principales:	Steffen, Jamin D., McCauley, Michael M., Pascal, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175350/ https://www.ncbi.nlm.nih.gov/pubmed/27530425 http://dx.doi.org/10.1093/nar/gkw710

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