Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method

Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the human ADAR2 deaminase domain bound to duplex...

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Detalles Bibliográficos
Autores principales: Wang, Yuru, Beal, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175354/
https://www.ncbi.nlm.nih.gov/pubmed/27614075
http://dx.doi.org/10.1093/nar/gkw799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175354/
https://www.ncbi.nlm.nih.gov/pubmed/27614075
http://dx.doi.org/10.1093/nar/gkw799

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