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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the human ADAR2 deaminase domain bound to duplex...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175354/ https://www.ncbi.nlm.nih.gov/pubmed/27614075 http://dx.doi.org/10.1093/nar/gkw799 |