Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase

Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised p...

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Detalles Bibliográficos
Autores principales: Topalis, D., Gillemot, S., Snoeck, R., Andrei, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175367/
https://www.ncbi.nlm.nih.gov/pubmed/27694307
http://dx.doi.org/10.1093/nar/gkw875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175367/
https://www.ncbi.nlm.nih.gov/pubmed/27694307
http://dx.doi.org/10.1093/nar/gkw875

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