Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

BACKGROUND: Study of age related macular degeneration (AMD) has been hampered by lack of human models that represent the complexity of the disease. Here we have developed a human in vitro disease model of AMD to investigate the underlying AMD disease mechanisms. METHODS: Generation of iPSCs from ret...

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Detalles Bibliográficos
Autores principales: Golestaneh, Nady, Chu, Yi, Cheng, Shuk Kei, Cao, Hong, Poliakov, Eugenia, Berinstein, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175395/
https://www.ncbi.nlm.nih.gov/pubmed/27998274
http://dx.doi.org/10.1186/s12967-016-1101-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175395/
https://www.ncbi.nlm.nih.gov/pubmed/27998274
http://dx.doi.org/10.1186/s12967-016-1101-8

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