Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model

Although the precise mechanism underlying initial lesion development in multiple sclerosis (MS) remains unclear, CNS inflammation has long been associated with demyelination, and axonal degeneration. The activation of microglia/macrophages, which serve as innate immune cells in the CNS, is the first...

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Detalles Bibliográficos
Autores principales: Liang, Junjie, Li, Ning, Zhang, Yanli, Hou, Changyi, Yang, Xiaohan, Shimizu, Takahiro, Wang, Xiaoyu, Ikenaka, Kazuhiro, Fan, Kai, Ma, Jianmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175397/
https://www.ncbi.nlm.nih.gov/pubmed/28066178
http://dx.doi.org/10.3389/fnmol.2016.00152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175397/
https://www.ncbi.nlm.nih.gov/pubmed/28066178
http://dx.doi.org/10.3389/fnmol.2016.00152

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