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Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

Inflammation influences chronic neurodegeneration but its precise roles are not yet clear. Systemic inflammation caused by infection, trauma or co-morbidity can alter the brain’s inflammatory status, produce acute cognitive impairments, such as delirium, and drive new pathology and accelerated decli...

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Detalles Bibliográficos
Autores principales: Hennessy, Edel, Gormley, Shane, Lopez-Rodriguez, Ana Belen, Murray, Caoimhe, Murray, Carol, Cunningham, Colm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176008/
https://www.ncbi.nlm.nih.gov/pubmed/27633985
http://dx.doi.org/10.1016/j.bbi.2016.09.011