Cargando…
Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration
Inflammation influences chronic neurodegeneration but its precise roles are not yet clear. Systemic inflammation caused by infection, trauma or co-morbidity can alter the brain’s inflammatory status, produce acute cognitive impairments, such as delirium, and drive new pathology and accelerated decli...
Autores principales: | Hennessy, Edel, Gormley, Shane, Lopez-Rodriguez, Ana Belen, Murray, Caoimhe, Murray, Carol, Cunningham, Colm |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176008/ https://www.ncbi.nlm.nih.gov/pubmed/27633985 http://dx.doi.org/10.1016/j.bbi.2016.09.011 |
Ejemplares similares
-
At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei
por: Reis, Renata, et al.
Publicado: (2015) -
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
por: Murray, Carol L, et al.
Publicado: (2011) -
Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
por: Nazmi, Arshed, et al.
Publicado: (2019) -
A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice
por: Skelly, Donal T., et al.
Publicado: (2013) -
Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1β, TNF-α and IL-6 Challenges in C57BL/6 Mice
por: Skelly, Donal T., et al.
Publicado: (2013)