Structural basis for subtype-specific inhibition of the P2X7 receptor

The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine triphosphate (ATP). Chronic activation of P2X7 underlies many health problems such as pathologic pain, yet we lack effective antagonists due to poorly understood mechanisms of inhibition. Here we present crystal...

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Detalles Bibliográficos
Autores principales: Karasawa, Akira, Kawate, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176352/
https://www.ncbi.nlm.nih.gov/pubmed/27935479
http://dx.doi.org/10.7554/eLife.22153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176352/
https://www.ncbi.nlm.nih.gov/pubmed/27935479
http://dx.doi.org/10.7554/eLife.22153

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