Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells

Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates H3K27me3 and is associated with transcriptional repression. PRC2 regulates cell-fate decisions in model organisms; however, its role in regulating cell differentiation during human embryogenesis is unknown. Here, we repor...

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Detalles Bibliográficos
Autores principales: Collinson, Adam, Collier, Amanda J., Morgan, Natasha P., Sienerth, Arnold R., Chandra, Tamir, Andrews, Simon, Rugg-Gunn, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177603/
https://www.ncbi.nlm.nih.gov/pubmed/27926872
http://dx.doi.org/10.1016/j.celrep.2016.11.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177603/
https://www.ncbi.nlm.nih.gov/pubmed/27926872
http://dx.doi.org/10.1016/j.celrep.2016.11.032

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