A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria

Mitochondrial dysfunction is implicated in numerous neurodegenerative disorders and in Parkinson’s disease (PD) in particular. PINK1 and Parkin gene mutations are causes of autosomal recessive PD, and these respective proteins function cooperatively to degrade depolarized mitochondria (mitophagy). I...

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Detalles Bibliográficos
Autores principales: Pryde, Kenneth Robert, Taanman, Jan Willem, Schapira, Anthony Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177631/
https://www.ncbi.nlm.nih.gov/pubmed/27926857
http://dx.doi.org/10.1016/j.celrep.2016.11.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177631/
https://www.ncbi.nlm.nih.gov/pubmed/27926857
http://dx.doi.org/10.1016/j.celrep.2016.11.027

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