The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H(3) Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice

Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer’s disease patients. An alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both histaminergic and cholinergic pathways, to create a synergistic effect...

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Detalles Bibliográficos
Autores principales: Sors, Aurore, Krazem, Ali, Kehr, Jan, Yoshitake, Takashi, Dominguez, Gaelle, Henkous, Nadia, Letondor, Claire, Mocaer, Elisabeth, Béracochéa, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177663/
https://www.ncbi.nlm.nih.gov/pubmed/28066242
http://dx.doi.org/10.3389/fphar.2016.00492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177663/
https://www.ncbi.nlm.nih.gov/pubmed/28066242
http://dx.doi.org/10.3389/fphar.2016.00492

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