Effects of initial telomere length distribution on senescence onset and heterogeneity

Replicative senescence, induced by telomere shortening, exhibits considerable asynchrony and heterogeneity, the origins of which remain unclear. Here, we formally study how telomere shortening mechanisms impact on senescence kinetics and define two regimes of senescence, depending on the initial tel...

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Detalles Bibliográficos
Autores principales: Eugène, Sarah, Bourgeron, Thibault, Xu, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177728/
https://www.ncbi.nlm.nih.gov/pubmed/27864096
http://dx.doi.org/10.1016/j.jtbi.2016.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177728/
https://www.ncbi.nlm.nih.gov/pubmed/27864096
http://dx.doi.org/10.1016/j.jtbi.2016.11.010

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