A20 Curtails Primary but Augments Secondary CD8(+) T Cell Responses in Intracellular Bacterial Infection

The ubiquitin-modifying enzyme A20, an important negative feedback regulator of NF-κB, impairs the expansion of tumor-specific CD8(+) T cells but augments the proliferation of autoimmune CD4(+) T cells. To study the T cell-specific function of A20 in bacterial infection, we infected T cell-specific...

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Detalles Bibliográficos
Autores principales: Just, Sissy, Nishanth, Gopala, Buchbinder, Jörn H., Wang, Xu, Naumann, Michael, Lavrik, Inna, Schlüter, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177869/
https://www.ncbi.nlm.nih.gov/pubmed/28004776
http://dx.doi.org/10.1038/srep39796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177869/
https://www.ncbi.nlm.nih.gov/pubmed/28004776
http://dx.doi.org/10.1038/srep39796

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