Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

The enzyme poly-ADP-ribose-polymerase (PARP) mediates DNA-repair and rearrangements of the nuclear chromatin. Generally, PARP activity is thought to promote cell survival and in recent years a number of PARP inhibitors have been clinically developed for cancer treatment. Paradoxically, PARP activity...

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Detalles Bibliográficos
Autores principales: Sahaboglu, Ayse, Barth, Melanie, Secer, Enver, Amo, Eva M. del, Urtti, Arto, Arsenijevic, Yvan, Zrenner, Eberhart, Paquet-Durand, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177898/
https://www.ncbi.nlm.nih.gov/pubmed/28004814
http://dx.doi.org/10.1038/srep39537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177898/
https://www.ncbi.nlm.nih.gov/pubmed/28004814
http://dx.doi.org/10.1038/srep39537

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