ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways

The vitally important skin barrier is formed by extensive cross-linking activity of transglutaminases (TGs) during terminal epidermal differentiation. We have previously shown that epidermal deficiency of a disintegrin and metalloproteinase 17 (ADAM17), the principal EGFR ligand sheddase, results in...

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Detalles Bibliográficos
Autores principales: Wolf , Cristina, Qian, Yawen, Brooke, Matthew A., Kelsell, David P., Franzke, Claus-Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177948/
https://www.ncbi.nlm.nih.gov/pubmed/28004780
http://dx.doi.org/10.1038/srep39780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177948/
https://www.ncbi.nlm.nih.gov/pubmed/28004780
http://dx.doi.org/10.1038/srep39780

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