Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration

One hallmark of Alzheimer´s disease are senile plaques consisting of amyloid beta (Aβ), which derives from the processing of the amyloid precursor protein (APP). Mitochondrial dysfunction has been linked to the pathogenesis of Alzheimer´s disease and both Aβ and APP have been reported to affect mito...

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Detalles Bibliográficos
Autores principales: Schaefer, Patrick M., von Einem, Bjoern, Walther, Paul, Calzia, Enrico, von Arnim, Christine A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178995/
https://www.ncbi.nlm.nih.gov/pubmed/28005987
http://dx.doi.org/10.1371/journal.pone.0168157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178995/
https://www.ncbi.nlm.nih.gov/pubmed/28005987
http://dx.doi.org/10.1371/journal.pone.0168157

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