Cargando…

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes

PURPOSE: To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients. METHODS: Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with Vitamin C stimulation in order t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Priyadarsini, Shrestha, Sarker-Nag, Akhee, Rowsey, Tyler G., Ma, Jian-Xing, Karamichos, Dimitrios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179241/ https://www.ncbi.nlm.nih.gov/pubmed/28005998 http://dx.doi.org/10.1371/journal.pone.0168845

Ejemplares similares

Keratoconus in vitro and the key players of the TGF-β pathway
por: Priyadarsini, Shrestha, et al.
Publicado: (2015)

Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease
por: Priyadarsini, Shrestha, et al.
Publicado: (2014)

Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma
por: Nicholas, Sarah E., et al.
Publicado: (2017)

Human Keratoconus Cell Contractility is Mediated by Transforming Growth Factor-Beta Isoforms
por: Lyon, Desiree’, et al.
Publicado: (2015)

Association between Diabetes and Keratoconus: A Retrospective Analysis
por: Whelchel, Amy E., et al.
Publicado: (2019)

Arginine Supplementation Promotes Extracellular Matrix and Metabolic Changes in Keratoconus
por: McKay, Tina B., et al.
Publicado: (2021)

The role of lipids in corneal diseases and dystrophies: a systematic review
por: Rowsey, Tyler G., et al.
Publicado: (2017)

Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus
por: McKay, Tina B., et al.
Publicado: (2019)

Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes
por: Shrestha, Pawan, et al.
Publicado: (2022)

Nerve influence on the metabolism of type I and type II diabetic corneal stroma: an in vitro study
por: Whelchel, Amy E., et al.
Publicado: (2021)

Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro
por: McKay, Tina B., et al.
Publicado: (2017)

Sex Hormones, Growth Hormone, and the Cornea
por: McKay, Tina B., et al.
Publicado: (2022)

Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells
por: Lam, Thi N., et al.
Publicado: (2021)

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus
por: McKay, T. B., et al.
Publicado: (2015)

Pathogenic Role of PPARα Downregulation in Corneal Nerve Degeneration and Impaired Corneal Sensitivity in Diabetes
por: Matlock, H. Greg, et al.
Publicado: (2020)

Quercetin Decreases Corneal Haze In Vivo and Influences Gene Expression of TGF-Beta Mediators In Vitro
por: McKay, Tina B., et al.
Publicado: (2022)

Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling
por: Liang, Wentao, et al.
Publicado: (2022)

Corneal Epithelial–Stromal Fibroblast Constructs to Study Cell–Cell Communication in Vitro
por: McKay, Tina B., et al.
Publicado: (2019)

FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro
por: Yeung, Vincent, et al.
Publicado: (2021)

A Method for Real-Time Assessment of Mitochondrial Respiration Using Murine Corneal Biopsy
por: Liang, Wentao, et al.
Publicado: (2023)

Treatment of Non-Infectious Corneal Injury: Review of Diagnostic Agents, Therapeutic Medications, and Future Targets
por: Dang, Deanna H., et al.
Publicado: (2022)

Transcriptional profiling of corneal stromal cells derived from patients with keratoconus
por: Sharif, Rabab, et al.
Publicado: (2019)

A Role for Topographic Cues in the Organization of Collagenous Matrix by Corneal Fibroblasts and Stem Cells
por: Karamichos, Dimitrios, et al.
Publicado: (2014)

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus
por: Van, Lyly, et al.
Publicado: (2023)

Novel Correlation between TGF-β1/-β3 and Hormone Receptors in the Human Corneal Stroma
por: Choi, Alexander J., et al.
Publicado: (2023)

Unravelling Novel Roles of Salivary Exosomes in the Regulation of Human Corneal Stromal Cell Migration and Wound Healing
por: Escandon, Paulina, et al.
Publicado: (2022)

Kynurenic Acid Accelerates Healing of Corneal Epithelium In Vitro and In Vivo
por: Matysik-Woźniak, Anna, et al.
Publicado: (2021)

Modeling Diabetic Corneal Neuropathy in a 3D In Vitro Cornea System
por: Deardorff, Phillip M., et al.
Publicado: (2018)

Acacia honey accelerates in vitro corneal ulcer wound healing model
por: Abd Ghafar, Norzana, et al.
Publicado: (2016)

Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro
por: McKay, Tina B., et al.
Publicado: (2017)

Ocular Complications of Diabetes and Therapeutic Approaches
por: Vieira-Potter, Victoria J., et al.
Publicado: (2016)

Human in vitro Model Reveals the Effects of Collagen Cross-linking on Keratoconus Pathogenesis
por: Sharif, Rabab, et al.
Publicado: (2017)

A New Era for Analytical Cellular Pathology
por: Karamichos, Dimitrios
Publicado: (2020)

Latest in Cellular Pathology Research
por: Karamichos, Dimitrios
Publicado: (2022)

Establishing a Mouse Model of Chlorpromazine-Induced Corneal Trigeminal Denervation
por: Lin, Xiongshi, et al.
Publicado: (2023)

The Parameters to Establish a New Corneal Dystrophy
por: Klintworth, Gordon K.
Publicado: (2011)

Novel in Vitro Model for Keratoconus Disease
por: Karamichos, Dimitrios, et al.
Publicado: (2012)

Keratoconus: Tissue Engineering and Biomaterials
por: Karamichos, Dimitrios, et al.
Publicado: (2014)

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model
por: Wilkerson, Joseph L., et al.
Publicado: (2022)

Standard versus accelerated riboflavin–ultraviolet corneal collagen crosslinking: Resistance against enzymatic digestion
por: Aldahlawi, Nada H., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2nrio6pe0v9m5rh2rk8a7p6ieg