Cargando…

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes

Although abundant genetic and biochemical evidence strongly links Clusterin (CLU) to Alzheimer disease (AD) pathogenesis, the receptor for CLU within the adult brain is currently unknown. Using unbiased approaches, we identified Plexin A4 (PLXNA4) as a novel, high-affinity receptor for CLU in the ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Silvia S., Kurti, Aishe, Wojtas, Aleksandra, Baker, Kelsey E., Liu, Chia-Chen, Kanekiyo, Takahisa, Deming, Yuetiva, Cruchaga, Carlos, Estus, Steven, Bu, Guojun, Fryer, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179943/ https://www.ncbi.nlm.nih.gov/pubmed/27378688 http://dx.doi.org/10.1093/hmg/ddw188

Ejemplares similares

Astrocyte-derived clusterin suppresses amyloid formation in vivo
por: Wojtas, Aleksandra M., et al.
Publicado: (2020)

APOE2 is associated with longevity independent of Alzheimer’s disease
por: Shinohara, Mitsuru, et al.
Publicado: (2020)

Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation
por: Wojtas, Aleksandra M., et al.
Publicado: (2020)

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
por: Kang, Silvia S, et al.
Publicado: (2018)

Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
por: Bu, Guojun, et al.
Publicado: (2013)

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk
por: Ling, I-Fang, et al.
Publicado: (2012)

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease
por: Kanekiyo, Takahisa, et al.
Publicado: (2014)

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
por: Inoue, Yasuteru, et al.
Publicado: (2023)

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
por: Kang, Silvia S, et al.
Publicado: (2014)

LRP1 plays a major role in the amyloid-β clearance in microglia
por: N’Songo, Aurelie, et al.
Publicado: (2013)

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
por: Chen, Fading, et al.
Publicado: (2021)

No Diagnostic Value of Plasma Clusterin in Alzheimer's Disease
por: Silajdžić, Edina, et al.
Publicado: (2012)

Clusterin transduces Alzheimer-risk signals to amyloidogenesis
por: Liu, Xi, et al.
Publicado: (2022)

Clusterin/apolipoprotein J, its isoforms and Alzheimer's disease
por: Milinkeviciute, Giedre, et al.
Publicado: (2023)

Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans
por: Del-Aguila, Jorge L., et al.
Publicado: (2015)

Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation
por: Neufeld, Shay Q, et al.
Publicado: (2011)

5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway
por: Shinohara, Motoko, et al.
Publicado: (2019)

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease
por: Fernández, Maria V., et al.
Publicado: (2018)

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
por: Yamazaki, Yu, et al.
Publicado: (2017)

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neurons
por: Gan, Ming, et al.
Publicado: (2014)

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins
por: Wylie, Thomas, et al.
Publicado: (2017)

Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling
por: Cowan, Richard, et al.
Publicado: (2023)

Alzheimer's risk variants in the clusterin gene are associated with alternative splicing
por: Szymanski, M, et al.
Publicado: (2011)

Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke
por: Weinstein, Galit, et al.
Publicado: (2016)

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
por: Bettens, Karolien, et al.
Publicado: (2015)

Development of a Label-Free Immunosensor for Clusterin Detection as an Alzheimer’s Biomarker
por: Islam, Kamrul, et al.
Publicado: (2018)

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies
por: Foster, Evangeline M., et al.
Publicado: (2019)

Clusterin as a Potential Biomarker of Obesity-Related Alzheimer’s Disease Risk
por: Bradley, David
Publicado: (2020)

Graphene FET Sensors for Alzheimer’s Disease Protein Biomarker Clusterin Detection
por: Bungon, Theodore, et al.
Publicado: (2021)

Dynamic changes of CSF clusterin levels across the Alzheimer’s disease continuum
por: Tang, Lian, et al.
Publicado: (2022)

ABCA7 and Pathogenic Pathways of Alzheimer’s Disease
por: Aikawa, Tomonori, et al.
Publicado: (2018)

Essential roles of plexin-B3(+) oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease
por: Nihonmatsu-Kikuchi, Naomi, et al.
Publicado: (2021)

Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
por: Adel, Susannah S., et al.
Publicado: (2023)

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model
por: Cook, Casey, et al.
Publicado: (2015)

Plexin Activation Relies on an Array of Receptors
por: Huang, Stephanie
Publicado: (2011)

Structural Basis for Plexin Activation and Regulation
por: Kong, Youxin, et al.
Publicado: (2016)

Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates
por: Junqueira Alves, Chrystian, et al.
Publicado: (2021)

Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer’s Disease
por: Chen, Ping, et al.
Publicado: (2013)

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers
por: Jackson, Rosemary J, et al.
Publicado: (2019)

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease
por: Fernández, Maria Victoria, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hmvci3md4ilegec7fak0a16i68