Cargando…

Genetic ablation of IP(3) receptor 2 increases cytokines and decreases survival of SOD1(G93A) mice

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease characterized by the selective death of motor neurons. Disease pathophysiology is complex and not yet fully understood. Higher gene expression of the inositol 1,4,5-trisphosphate receptor 2 gene (ITPR2), encod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Staats, Kim A., Humblet-Baron, Stephanie, Bento-Abreu, Andre, Scheveneels, Wendy, Nikolaou, Alexandros, Deckers, Kato, Lemmens, Robin, Goris, An, Van Ginderachter, Jo A., Van Damme, Philip, Hisatsune, Chihiro, Mikoshiba, Katsuhiko, Liston, Adrian, Robberecht, Wim, Van Den Bosch, Ludo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179944/ https://www.ncbi.nlm.nih.gov/pubmed/27378687 http://dx.doi.org/10.1093/hmg/ddw190

Ejemplares similares

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1(G93A) mice
por: Eykens, Caroline, et al.
Publicado: (2018)

Rapamycin increases survival in ALS mice lacking mature lymphocytes
por: Staats, Kim A, et al.
Publicado: (2013)

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins
por: Steyaert, Jolien, et al.
Publicado: (2018)

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis
por: Staats, Kim A., et al.
Publicado: (2013)

Modelling amyotrophic lateral sclerosis: progress and possibilities
por: Van Damme, Philip, et al.
Publicado: (2017)

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
por: Pollari, Eveliina, et al.
Publicado: (2018)

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis
por: Rué, Laura, et al.
Publicado: (2019)

IP(3)R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
por: Hisatsune, Chihiro, et al.
Publicado: (2013)

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
por: Herdewyn, Sarah, et al.
Publicado: (2014)

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot–Marie–Tooth Disease
por: Benoy, Veronick, et al.
Publicado: (2016)

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
por: Beel, Sander, et al.
Publicado: (2017)

Astrocytic IP(3)Rs: Beyond IP(3)R2
por: Sherwood, Mark W., et al.
Publicado: (2021)

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
por: Benoy, Veronick, et al.
Publicado: (2018)

Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy
por: Laird, Angela S., et al.
Publicado: (2010)

RNA toxicity in non‐coding repeat expansion disorders
por: Swinnen, Bart, et al.
Publicado: (2019)

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy
por: Poppe, Lindsay, et al.
Publicado: (2019)

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity
por: Bogaert, Elke, et al.
Publicado: (2018)

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
por: Beel, Sander, et al.
Publicado: (2018)

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
por: Drawnel, Faye M., et al.
Publicado: (2012)

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
por: Van Damme, Philip, et al.
Publicado: (2008)

A Technique for Performing Electrical Impedance Myography in the Mouse Hind Limb: Data in Normal and ALS SOD1 G93A Animals
por: Li, Jia, et al.
Publicado: (2012)

Non-invasive assessment of disease progression and neuroprotective effects of dietary coconut oil supplementation in the ALS SOD1(G93A) mouse model: A (1)H-magnetic resonance spectroscopic study
por: Weerasekera, A., et al.
Publicado: (2018)

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification
por: Bento-Abreu, Andre, et al.
Publicado: (2018)

Neuromuscular effects of G93A-SOD1 expression in zebrafish
por: Sakowski, Stacey A, et al.
Publicado: (2012)

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
por: Boeynaems, Steven, et al.
Publicado: (2016)

Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ
por: Chamero, Pablo, et al.
Publicado: (2017)

Depotentiation depends on IP(3) receptor activation sustained by synaptic inputs after LTP induction
por: Fujii, Satoshi, et al.
Publicado: (2020)

Metabolic Changes Associated With Muscle Expression of SOD1(G93A)
por: Dobrowolny, Gabriella, et al.
Publicado: (2018)

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis
por: Rué, Laura, et al.
Publicado: (2019)

Corrigendum: Depotentiation depends on IP(3) receptor activation sustained by synaptic inputs after LTP induction
por: Fujii, Satoshi, et al.
Publicado: (2023)

Mice Lacking Inositol 1,4,5-Trisphosphate Receptors Exhibit Dry Eye
por: Inaba, Takaaki, et al.
Publicado: (2014)

EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease
por: Poppe, Lindsay, et al.
Publicado: (2019)

Chlorovirus ATCV-1 Accelerates Motor Deterioration in SOD1-G93A Transgenic Mice and Its SOD1 Augments Induction of Inflammatory Factors From Murine Macrophages
por: Petro, Thomas M., et al.
Publicado: (2022)

Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates
por: Borel, Florie, et al.
Publicado: (2016)

A closer look at the SOD1(G93Adl) mouse model of ALS
Publicado: (2011)

Genetic Biomarkers for ALS Disease in Transgenic SOD1(G93A) Mice
por: Calvo, Ana C., et al.
Publicado: (2012)

Characterization of somatosensory neuron involvement in the SOD1(G93A) mouse model
por: Rubio, Miguel A., et al.
Publicado: (2022)

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD
por: Boeynaems, Steven, et al.
Publicado: (2016)

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS
por: Eykens, Caroline, et al.
Publicado: (2021)

Identification and characterization of Nanobodies targeting the EphA4 receptor
por: Schoonaert, Lies, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n46i7tld3f8u8sb7m49g0vn6ij