Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5

CCR5 stimulation with natural ligands, such as RANTES, classically induces short-term internalization with transient activation of β-arrestins and rapidly recycling on the cell surface. Here we discovered that, in T cells, natural CCR5 antibodies induce a CCR5-negative phenotype with the involvement...

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Detalles Bibliográficos
Autores principales: Venuti, Assunta, Pastori, Claudia, Pennisi, Rosamaria, Riva, Agostino, Sciortino, Maria Teresa, Lopalco, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180096/
https://www.ncbi.nlm.nih.gov/pubmed/28008933
http://dx.doi.org/10.1038/srep39382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180096/
https://www.ncbi.nlm.nih.gov/pubmed/28008933
http://dx.doi.org/10.1038/srep39382

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