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Translocation of the thioesterase domain for the redesign of plipastatin synthetase

Non-ribosomal peptide synthetases (NRPSs) are large enzymatic complexes that catalyse the synthesis of biologically active peptides in microorganisms. Genetic engineering has recently been applied to reprogram NRPSs to produce lipopeptides with a new sequence. The carboxyl-terminal thioesterase (TE)...

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Detalles Bibliográficos
Autores principales: Gao, Ling, Liu, Hongxia, Ma, Zhi, Han, Jinzhi, Lu, Zhaoxin, Dai, Chen, Lv, Fengxia, Bie, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180189/
https://www.ncbi.nlm.nih.gov/pubmed/28009004
http://dx.doi.org/10.1038/srep38467