Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis

Thalidomide can modulate the TNFα-NFκB and iNOS pathway, which involve in the pathogenesis of hepatopulmonary syndrome (HPS) and muscle wasting in cirrhosis. In bile duct ligated-cirrhotic rats, the increased circulating CD16(+) (inflammatory) monocytes and its intracellular TNFα, NFκB, monocyte che...

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Detalles Bibliográficos
Autores principales: Li, Tzu-Hao, Lee, Pei-Chang, Lee, Kuei-Chuan, Hsieh, Yun-Cheng, Tsai, Chang-Youh, Yang, Ying-Ying, Huang, Shiang-Fen, Tsai, Tung-Hu, Hsieh, Shie-Liang, Hou, Ming-Chih, Lin, Han-Chieh, Lee, Shou-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180197/
https://www.ncbi.nlm.nih.gov/pubmed/28009008
http://dx.doi.org/10.1038/srep39405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180197/
https://www.ncbi.nlm.nih.gov/pubmed/28009008
http://dx.doi.org/10.1038/srep39405

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