Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

Amyloid precursor protein (APP), commonly associated with Alzheimer’s disease, also marks axonal degeneration. In the recent studies, we demonstrated that APP aggregated at nodes of Ranvier (NORs) in myelinated central nervous system (CNS) axons and interacted with Nav1.6. However, the physiological...

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Detalles Bibliográficos
Autores principales: Li, Shao, Wang, Xi, Ma, Quan-Hong, Yang, Wu-lin, Zhang, Xiao-Gang, Dawe, Gavin S., Xiao, Zhi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://www.ncbi.nlm.nih.gov/pubmed/28008944
http://dx.doi.org/10.1038/srep39320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180232/
https://www.ncbi.nlm.nih.gov/pubmed/28008944
http://dx.doi.org/10.1038/srep39320

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