Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation

G protein-coupled receptors (GPCRs) modulate cytoplasmic signalling in response to extracellular stimuli, and are important therapeutic targets in a wide range of diseases. Structure determination of GPCRs in all activation states is important to elucidate the precise mechanism of signal transductio...

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Detalles Bibliográficos
Autores principales: Carpenter, Byron, Tate, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181381/
https://www.ncbi.nlm.nih.gov/pubmed/27672048
http://dx.doi.org/10.1093/protein/gzw049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181381/
https://www.ncbi.nlm.nih.gov/pubmed/27672048
http://dx.doi.org/10.1093/protein/gzw049

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