Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism

Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was identified 20 years ago, it has proven difficult to inv...

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Detalles Bibliográficos
Autores principales: Gallotta, Ivan, Mazzarella, Nadia, Donato, Alessandra, Esposito, Alessandro, Chaplin, Justin C., Castro, Silvana, Zampi, Giuseppina, Battaglia, Giorgio S., Hilliard, Massimo A., Bazzicalupo, Paolo, Di Schiavi, Elia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181630/
https://www.ncbi.nlm.nih.gov/pubmed/27260405
http://dx.doi.org/10.1093/hmg/ddw119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181630/
https://www.ncbi.nlm.nih.gov/pubmed/27260405
http://dx.doi.org/10.1093/hmg/ddw119

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