Cargando…

Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism

Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was identified 20 years ago, it has proven difficult to inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallotta, Ivan, Mazzarella, Nadia, Donato, Alessandra, Esposito, Alessandro, Chaplin, Justin C., Castro, Silvana, Zampi, Giuseppina, Battaglia, Giorgio S., Hilliard, Massimo A., Bazzicalupo, Paolo, Di Schiavi, Elia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181630/ https://www.ncbi.nlm.nih.gov/pubmed/27260405 http://dx.doi.org/10.1093/hmg/ddw119

Ejemplares similares

Silencing of Syntaxin 1A in the Dopaminergic Neurons Decreases the Activity of the Dopamine Transporter and Prevents Amphetamine-Induced Behaviors in C. elegans
por: Lanzo, Ambra, et al.
Publicado: (2018)

Green kiwifruit extracts protect motor neurons from death in a spinal muscular atrophy model in Caenorhabditis elegans
por: Mazzarella, Nadia, et al.
Publicado: (2019)

Caenorhabditis elegans employs innate and learned aversion in response to bacterial toxic metabolites tambjamine and violacein
por: Ballestriero, Francesco, et al.
Publicado: (2016)

Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures
por: Pletto, Daniela, et al.
Publicado: (2018)

The G Protein regulators EGL-10 and EAT-16, the G(i)α GOA-1 and the G(q)α EGL-30 modulate the response of the C. elegans ASH polymodal nociceptive sensory neurons to repellents
por: Esposito, Giovanni, et al.
Publicado: (2010)

Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes
por: Gumeni, Sentiljana, et al.
Publicado: (2021)

CRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons
por: Straub, Christoph, et al.
Publicado: (2014)

Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster
por: Matera, A. Gregory, et al.
Publicado: (2018)

The role of survival motor neuron protein (SMN) in protein homeostasis
por: Chaytow, Helena, et al.
Publicado: (2018)

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans
por: Sangaletti, Rachele, et al.
Publicado: (2017)

Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons
por: Rizzo, Federica, et al.
Publicado: (2019)

Genomic Variability in the Survival Motor Neuron Genes (SMN1 and SMN2): Implications for Spinal Muscular Atrophy Phenotype and Therapeutics Development
por: Butchbach, Matthew E. R.
Publicado: (2021)

Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology
por: Solchenberger, Barbara, et al.
Publicado: (2015)

Neuronal sub‐compartmentalization: a strategy to optimize neuronal function
por: Donato, Alessandra, et al.
Publicado: (2019)

Survival Motor Neuron (SMN) protein is required for normal mouse liver development
por: Szunyogova, Eva, et al.
Publicado: (2016)

Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells
por: Custer, Sara K., et al.
Publicado: (2016)

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides
por: Frankowski, Harald, et al.
Publicado: (2021)

Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS
por: Kao, Ching Serena, et al.
Publicado: (2020)

Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
por: Petri, Sebastian, et al.
Publicado: (2007)

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis
por: Cucchiarini, Magali, et al.
Publicado: (2014)

Corrigendum: Survival Motor Neuron (SMN) protein is required for normal mouse liver development
por: Szunyogova, Eva, et al.
Publicado: (2016)

Survival Motor Neuron (SMN) Protein Insufficiency Exacerbates Renal Ischemia/Reperfusion Injury
por: Qian, Xiaoqian, et al.
Publicado: (2019)

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration
por: Watson-Scales, Sheona, et al.
Publicado: (2018)

Mouse Survival Motor Neuron Alleles That Mimic SMN2 Splicing and Are Inducible Rescue Embryonic Lethality Early in Development but Not Late
por: Hammond, Suzan M., et al.
Publicado: (2010)

In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons
por: Baker, Mark D., et al.
Publicado: (2011)

Survival motor neuron (SMN) polymorphism in relation to congenital arthrogryposis in two Piedmont calves (piemontese)
por: Longeri, Maria, et al.
Publicado: (2003)

Molecular Determinants of Survival Motor Neuron (SMN) Protein Cleavage by the Calcium-Activated Protease, Calpain
por: Fuentes, Jennifer L., et al.
Publicado: (2010)

Rapid conditional knock-down–knock-in system for mammalian cells
por: Hölzel, Michael, et al.
Publicado: (2007)

Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo
por: Waldron, Ashley, et al.
Publicado: (2019)

Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding
por: McWhorter, Michelle L., et al.
Publicado: (2003)

Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy
por: Cottam, Nicholas C., et al.
Publicado: (2023)

Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells
por: Cheng, Yu-Che, et al.
Publicado: (2016)

Knocked down a Notch with age
por: LeBrasseur, Nicole
Publicado: (2003)

Knocking down Disease with siRNAs
por: Dykxhoorn, Derek M., et al.
Publicado: (2006)

AAV9-Mediated Expression of SMN Restricted to Neurons Does Not Rescue the Spinal Muscular Atrophy Phenotype in Mice
por: Besse, Aurore, et al.
Publicado: (2020)

Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn(2B/)(-) mouse model of SMA
por: Carlini, Maria J., et al.
Publicado: (2022)

Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice
por: Tejero, Rocio, et al.
Publicado: (2023)

Corrigendum: Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells
por: Cheng, Yu-Che, et al.
Publicado: (2016)

Overexpression of X-Linked Inhibitor of Apoptotic Protein (XIAP) Reduces Age-related Neuronal Degeneration in the Mouse Cochlea
por: Ruan, Qingwei, et al.
Publicado: (2014)

Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein E-conjugated liposomes to the hippocampus
por: Kuo, Yung-Chih, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n6dltsr2n2t6gq3vm94ria09io