LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease

Background: Modulation of gene transcription by HDAC inhibitors has been shown repeatedly to be neuroprotective in cellular, invertebrate, and rodent models of Huntington’s disease (HD). It has been difficult to translate these treatments to the clinic, however, because existing compounds have limit...

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Detalles Bibliográficos
Autores principales: Chopra, Vanita, Quinti, Luisa, Khanna, Prarthana, Paganetti, Paolo, Kuhn, Rainer, Young, Anne B., Kazantsev, Aleksey G., Hersch, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181668/
https://www.ncbi.nlm.nih.gov/pubmed/27983565
http://dx.doi.org/10.3233/JHD-160226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181668/
https://www.ncbi.nlm.nih.gov/pubmed/27983565
http://dx.doi.org/10.3233/JHD-160226

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