AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway

The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy metabolism, and promotes mitochondrial proliferation and apoptosis. Previous studies have shown that AICAR has anticancer effects in various cancers, however the roles of...

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Detalles Bibliográficos
Autores principales: Morishita, Masayuki, Kawamoto, Teruya, Hara, Hitomi, Onishi, Yasuo, Ueha, Takeshi, Minoda, Masaya, Katayama, Etsuko, Takemori, Toshiyuki, Fukase, Naomasa, Kurosaka, Masahiro, Kuroda, Ryosuke, Akisue, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182012/
https://www.ncbi.nlm.nih.gov/pubmed/27878239
http://dx.doi.org/10.3892/ijo.2016.3775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182012/
https://www.ncbi.nlm.nih.gov/pubmed/27878239
http://dx.doi.org/10.3892/ijo.2016.3775

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