Cargando…

AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway

The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) modulates cellular energy metabolism, and promotes mitochondrial proliferation and apoptosis. Previous studies have shown that AICAR has anticancer effects in various cancers, however the roles of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morishita, Masayuki, Kawamoto, Teruya, Hara, Hitomi, Onishi, Yasuo, Ueha, Takeshi, Minoda, Masaya, Katayama, Etsuko, Takemori, Toshiyuki, Fukase, Naomasa, Kurosaka, Masahiro, Kuroda, Ryosuke, Akisue, Toshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182012/ https://www.ncbi.nlm.nih.gov/pubmed/27878239 http://dx.doi.org/10.3892/ijo.2016.3775

Ejemplares similares

Huge chronic expanding hematoma of the iliac bone following multiple hip surgeries: a case report
por: Morishita, Masayuki, et al.
Publicado: (2018)

‘Decoy’ and ‘non-decoy’ functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells
por: TODA, MITSUNORI, et al.
Publicado: (2013)

Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS
por: MINODA, MASAYA, et al.
Publicado: (2015)

Transcutaneous Application of Carbon Dioxide (CO(2)) Induces Mitochondrial Apoptosis in Human Malignant Fibrous Histiocytoma In Vivo
por: Onishi, Yasuo, et al.
Publicado: (2012)

Regulation of Mitochondrial Proliferation by PGC-1α Induces Cellular Apoptosis in Musculoskeletal Malignancies
por: Onishi, Yasuo, et al.
Publicado: (2014)

Gemcitabine and docetaxel combination chemotherapy for advanced bone and soft tissue sarcomas: protocol for an open-label, non-randomised, Phase 2 study
por: Hara, Hitomi, et al.
Publicado: (2019)

Chondrolipoma of the finger in a child: A case study
por: Mitani, Kazuyoshi, et al.
Publicado: (2021)

Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision
por: Takemori, Toshiyuki, et al.
Publicado: (2022)

Sequential MR Images and Radiographs of Epiphyseal Osteomyelitis in the Distal Femur of an Infant
por: Hara, Hitomi, et al.
Publicado: (2013)

Identification and characterization of slow-cycling cells in Ewing sarcoma
por: Yahiro, Shunsuke, et al.
Publicado: (2022)

Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo
por: Takeda, Daisuke, et al.
Publicado: (2014)

Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors
por: Fujiwara, Shuichi, et al.
Publicado: (2020)

A rare case of acute osteomyelitis due to Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus in a young healthy adult
por: Takemori, Toshiyuki, et al.
Publicado: (2017)

Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases)
por: Hara, Hitomi, et al.
Publicado: (2021)

Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report
por: Yahiro, Shunsuke, et al.
Publicado: (2022)

Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis
por: Kitayama, Kazumichi, et al.
Publicado: (2021)

AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy
por: Rae, Colin, et al.
Publicado: (2019)

Pneumocephalus Associated with Cerebrospinal Fluid Fistula as a Complication of Spinal Surgery: A Case Report
por: Sasaki, Ken, et al.
Publicado: (2010)

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses
por: Rao, Enyu, et al.
Publicado: (2016)

AMPK-independent inhibition of human macrophage ER stress response by AICAR
por: Boß, Marcel, et al.
Publicado: (2016)

Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan
por: Takemori, Toshiyuki, et al.
Publicado: (2022)

AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
por: Višnjić, Dora, et al.
Publicado: (2021)

A Case of Acute Prosthesis Migration after Femoral Head Replacement due to Osteomalacia by FGF23-Induced Tumor
por: Hayashi, Shinya, et al.
Publicado: (2012)

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
por: Kobilo, Tali, et al.
Publicado: (2014)

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
por: Chen, Kuan-Hsing, et al.
Publicado: (2014)

AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
por: Liu, Shudong, et al.
Publicado: (2015)

Nodular fasciitis of the hand in a young athlete. A case report
por: Hara, Hitomi, et al.
Publicado: (2010)

The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?
por: Menassol, Jean-Baptiste, et al.
Publicado: (2011)

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2
por: Philippe, Chloé, et al.
Publicado: (2018)

Multiple huge subchondral cysts associated with pseudogout in the bilateral knees: a case report and review of the literatures
por: Minoda, Masaya, et al.
Publicado: (2011)

Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism
por: Chun, Min Jeong, et al.
Publicado: (2017)

AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model
por: Hu, Liangshuo, et al.
Publicado: (2019)

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport
por: Knudsen, Jonas R., et al.
Publicado: (2020)

Polyostotic Fibrous Dysplasia with Epiphyseal Involvement in Long Bones: A Case Report
por: Fukui, Tomoaki, et al.
Publicado: (2013)

AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation
por: Lanner, Johanna T., et al.
Publicado: (2012)

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
por: Leclerc, Gilles M, et al.
Publicado: (2010)

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
por: Bultot, Laurent, et al.
Publicado: (2016)

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
por: Hall, Derek T, et al.
Publicado: (2018)

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway
por: Su, Chia-Cheng, et al.
Publicado: (2019)

Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation
por: Sui, Xinbing, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_84174jr92s2pshk7nllg75c8pm