Syrosingopine sensitizes cancer cells to killing by metformin

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine’s known role as an inhibitor...

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Detalles Bibliográficos
Autores principales: Benjamin, Don, Colombi, Marco, Hindupur, Sravanth K., Betz, Charles, Lane, Heidi A., El-Shemerly, Mahmoud Y. M., Lu, Min, Quagliata, Luca, Terracciano, Luigi, Moes, Suzette, Sharpe, Timothy, Wodnar-Filipowicz, Aleksandra, Moroni, Christoph, Hall, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182053/
https://www.ncbi.nlm.nih.gov/pubmed/28028542
http://dx.doi.org/10.1126/sciadv.1601756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182053/
https://www.ncbi.nlm.nih.gov/pubmed/28028542
http://dx.doi.org/10.1126/sciadv.1601756

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