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Amending Koch's postulates for viral disease: When “growth in pure culture” leads to a loss of virulence
It is a common laboratory practice to propagate viruses in cell culture. While convenient, these methodologies often result in unintentional genetic alterations, which have led to adaptation and even attenuation in animal models of disease. An example is the attenuation of hantaviruses (family: Buny...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182102/ https://www.ncbi.nlm.nih.gov/pubmed/27832942 http://dx.doi.org/10.1016/j.antiviral.2016.11.002 |