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Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor
Nerve Growth Factor (NGF), the prototype of the neurotrophin family, is essential for maintenance and growth of different neuronal populations. The X-ray crystal structure of NGF has been known since the early '90s and shows a β-sandwich fold with extensive loops that are involved in the intera...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183593/ https://www.ncbi.nlm.nih.gov/pubmed/28083536 http://dx.doi.org/10.3389/fmolb.2016.00083 |